Drug interactions
Lorcaserin + Propranolol
Severity: Minor
Lorcaserin and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a CYP2D6 inhibitor and could raise propranolol concentrations, but propranolol also has other metabolic routes so the effect is probably small. Lorcaserin has been withdrawn from the market in many regions.
What this interaction means in plain words
Lorcaserin and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lorcaserin inhibits CYP2D6, slightly reducing propranolol metabolism.
What to do
Monitor heart rate and blood pressure and adjust propranolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Lorcaserin with Propranolol?
MediHelp rates the interaction as minor. Lorcaserin and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorcaserin is a CYP2D6 inhibitor and could raise propranolol concentrations, but propranolol also has other metabolic routes so the effect is probably small. Lorcaserin has been withdrawn from the market in many regions.
How serious is the interaction between Lorcaserin and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and adjust propranolol dose if bradycardia or hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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