Drug interactions
Lorcaserin + Rasagiline
Severity: Major
Lorcaserin and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an MAO inhibitor may increase the risk of serotonin syndrome. Lorcaserin has been withdrawn from the US market, so it is rarely encountered.
What this interaction means in plain words
Lorcaserin and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Serotonergic activity combined with MAO inhibition may enhance serotonergic effects.
What to do
Avoid the combination. If it occurs, monitor for agitation, tremor, hyperthermia and autonomic instability and stop lorcaserin if they appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Lorcaserin with Rasagiline?
MediHelp rates the interaction as major. Lorcaserin and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an MAO inhibitor may increase the risk of serotonin syndrome. Lorcaserin has been withdrawn from the US market, so it is rarely encountered.
How serious is the interaction between Lorcaserin and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it occurs, monitor for agitation, tremor, hyperthermia and autonomic instability and stop lorcaserin if they appear.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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