Drug interactions
Lorcaserin + Selegiline
Severity: Major
Lorcaserin and Selegiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist and MAO inhibitors can raise serotonergic activity. The combination may increase the risk of serotonin syndrome, with agitation, hyperthermia, tremor and autonomic instability.
What this interaction means in plain words
Lorcaserin and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity combined with MAO inhibition.
What to do
Avoid combined use. Monitor for serotonin syndrome if overlap cannot be avoided, and stop the serotonergic drug if symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Lorcaserin with Selegiline?
MediHelp rates the interaction as major. Lorcaserin and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorcaserin is a serotonin 5-HT2C agonist and MAO inhibitors can raise serotonergic activity. The combination may increase the risk of serotonin syndrome, with agitation, hyperthermia, tremor and autonomic instability.
How serious is the interaction between Lorcaserin and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use. Monitor for serotonin syndrome if overlap cannot be avoided, and stop the serotonergic drug if symptoms occur.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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