Drug interactions
Lorcaserin + Tolterodine
Severity: Minor
Lorcaserin and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin inhibits CYP2D6 and could raise tolterodine levels, although CYP3A4 can compensate. Lorcaserin has been withdrawn from the market in many regions.
What this interaction means in plain words
Lorcaserin and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP2D6 inhibition by lorcaserin reduces formation of tolterodine's active metabolite and clearance of the parent drug.
What to do
Monitor for anticholinergic adverse effects; dose adjustment is rarely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Lorcaserin with Tolterodine?
MediHelp rates the interaction as minor. Lorcaserin and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorcaserin inhibits CYP2D6 and could raise tolterodine levels, although CYP3A4 can compensate. Lorcaserin has been withdrawn from the market in many regions.
How serious is the interaction between Lorcaserin and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects; dose adjustment is rarely needed.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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