Drug interactions
Lorlatinib + Lumefantrine
Severity: Moderate
Lorlatinib and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is metabolized by CYP3A4, and lorlatinib may reduce its concentrations. Lower exposure risks antimalarial treatment failure.
What this interaction means in plain words
Lorlatinib and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing lumefantrine metabolism.
What to do
Monitor for treatment failure and parasite clearance. Consider an alternative antimalarial if lorlatinib cannot be withheld.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Lumefantrine?
MediHelp rates the interaction as moderate. Lorlatinib and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is metabolized by CYP3A4, and lorlatinib may reduce its concentrations. Lower exposure risks antimalarial treatment failure.
How serious is the interaction between Lorlatinib and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure and parasite clearance. Consider an alternative antimalarial if lorlatinib cannot be withheld.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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