Drug interactions
Lorlatinib + Marijuana
Severity: Minor
Lorlatinib and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as THC and CBD are partly metabolized by CYP3A4, so lorlatinib may lower their levels. The clinical effect is uncertain and likely small.
What this interaction means in plain words
Lorlatinib and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lorlatinib induces CYP3A4, which may modestly increase cannabinoid metabolism.
What to do
No specific action is needed beyond awareness. Reassess symptom control if a medicinal cannabis product seems less effective.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Marijuana?
MediHelp rates the interaction as minor. Lorlatinib and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids such as THC and CBD are partly metabolized by CYP3A4, so lorlatinib may lower their levels. The clinical effect is uncertain and likely small.
How serious is the interaction between Lorlatinib and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond awareness. Reassess symptom control if a medicinal cannabis product seems less effective.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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