Drug interactions
Lorlatinib + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Major
Lorlatinib and Ombitasvir / paritaprevir / ritonavir and dasabuvir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A and may reduce concentrations of paritaprevir, ritonavir and other components of this regimen. This risks reduced antiviral efficacy and treatment failure. Ritonavir, a strong CYP3A inhibitor, may in turn increase lorlatinib exposure and toxicity.
What this interaction means in plain words
Lorlatinib and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Lorlatinib induces CYP3A4, increasing metabolism of the CYP3A-dependent components of the regimen.
What to do
Avoid concurrent use and select an alternative HCV regimen or ALK inhibitor. If unavoidable, monitor HCV RNA and lorlatinib toxicity including lipids and liver enzymes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lorlatinib and Ombitasvir / paritaprevir / ritonavir and dasabuvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as major. Lorlatinib and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib induces CYP3A and may reduce concentrations of paritaprevir, ritonavir and other components of this regimen. This risks reduced antiviral efficacy and treatment failure. Ritonavir, a strong CYP3A inhibitor, may in turn increase lorlatinib exposure and toxicity.
How serious is the interaction between Lorlatinib and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select an alternative HCV regimen or ALK inhibitor. If unavoidable, monitor HCV RNA and lorlatinib toxicity including lipids and liver enzymes.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
