Drug interactions
Lorlatinib + Pentobarbital
Severity: Contraindicated
Lorlatinib and Pentobarbital: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent inducers of CYP3A4 and can markedly lower lorlatinib concentrations, risking loss of tumour control. The strong inducer rifampin was also associated with liver enzyme elevations when given with lorlatinib. Labeling contraindicates strong CYP3A inducers.
What this interaction means in plain words
Lorlatinib and Pentobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Induction of CYP3A4 accelerates lorlatinib metabolism and lowers exposure.
What to do
Do not combine; choose a non-inducing sedative or anticonvulsant. If an inducer was used, stop it for about 3 half-lives before starting lorlatinib.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Pentobarbital?
MediHelp rates the interaction as contraindicated. Lorlatinib and Pentobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates are potent inducers of CYP3A4 and can markedly lower lorlatinib concentrations, risking loss of tumour control. The strong inducer rifampin was also associated with liver enzyme elevations when given with lorlatinib. Labeling contraindicates strong CYP3A inducers.
How serious is the interaction between Lorlatinib and Pentobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-inducing sedative or anticonvulsant. If an inducer was used, stop it for about 3 half-lives before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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