Drug interactions
Lorlatinib + Progesterone intravaginal
Severity: Moderate
Lorlatinib and Progesterone intravaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib can induce CYP3A and may reduce progesterone exposure, potentially lowering the efficacy of luteal support. Systemic exposure from vaginal gel is meaningful. Lorlatinib may also reduce effectiveness of hormonal contraception.
What this interaction means in plain words
Lorlatinib and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing progesterone metabolism.
What to do
Monitor for reduced progesterone effect, such as breakthrough bleeding or failed luteal support, and consider dose adjustment. Advise non-hormonal contraception where relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Progesterone intravaginal?
MediHelp rates the interaction as moderate. Lorlatinib and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib can induce CYP3A and may reduce progesterone exposure, potentially lowering the efficacy of luteal support. Systemic exposure from vaginal gel is meaningful. Lorlatinib may also reduce effectiveness of hormonal contraception.
How serious is the interaction between Lorlatinib and Progesterone intravaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced progesterone effect, such as breakthrough bleeding or failed luteal support, and consider dose adjustment. Advise non-hormonal contraception where relevant.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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