Drug interactions
Lorlatinib + Progesterone micronized
Severity: Moderate
Lorlatinib and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone is extensively metabolized by CYP3A4, and lorlatinib may lower its exposure. This can reduce endometrial protection or therapeutic effect.
What this interaction means in plain words
Lorlatinib and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing progesterone metabolism.
What to do
Monitor for loss of progestogenic effect such as breakthrough bleeding and adjust dose if needed; in patients on estrogen therapy, ensure adequate endometrial protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Progesterone micronized?
MediHelp rates the interaction as moderate. Lorlatinib and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral micronized progesterone is extensively metabolized by CYP3A4, and lorlatinib may lower its exposure. This can reduce endometrial protection or therapeutic effect.
How serious is the interaction between Lorlatinib and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of progestogenic effect such as breakthrough bleeding and adjust dose if needed; in patients on estrogen therapy, ensure adequate endometrial protection.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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