Drug interactions
Lorlatinib + Sufentanil sl
Severity: Moderate
Lorlatinib and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower sufentanil exposure. Reduced analgesia may result, and in opioid-dependent patients withdrawal symptoms may appear. If lorlatinib is later stopped, sufentanil levels may rise and increase the risk of opioid toxicity.
What this interaction means in plain words
Lorlatinib and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing the metabolism of sufentanil.
What to do
Monitor analgesic response and withdrawal signs while both drugs are used, and titrate sufentanil as needed. After lorlatinib is discontinued, watch for sedation and respiratory depression and reduce the opioid dose if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Sufentanil sl?
MediHelp rates the interaction as moderate. Lorlatinib and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower sufentanil exposure. Reduced analgesia may result, and in opioid-dependent patients withdrawal symptoms may appear. If lorlatinib is later stopped, sufentanil levels may rise and increase the risk of opioid toxicity.
How serious is the interaction between Lorlatinib and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and withdrawal signs while both drugs are used, and titrate sufentanil as needed. After lorlatinib is discontinued, watch for sedation and respiratory depression and reduce the opioid dose if required.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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