Drug interactions
Lorlatinib + Tezacaftor
Severity: Moderate
Lorlatinib and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower tezacaftor exposure through CYP3A4 induction. Reduced levels may diminish CFTR modulator benefit in cystic fibrosis.
What this interaction means in plain words
Lorlatinib and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing metabolism of tezacaftor, a CYP3A substrate.
What to do
Monitor lung function and clinical response to tezacaftor/ivacaftor. Consider avoiding the combination if efficacy drops, since strong inducers are not recommended with this therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Tezacaftor?
MediHelp rates the interaction as moderate. Lorlatinib and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may lower tezacaftor exposure through CYP3A4 induction. Reduced levels may diminish CFTR modulator benefit in cystic fibrosis.
How serious is the interaction between Lorlatinib and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lung function and clinical response to tezacaftor/ivacaftor. Consider avoiding the combination if efficacy drops, since strong inducers are not recommended with this therapy.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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