Drug interactions
Lorlatinib + Zanubrutinib
Severity: Moderate
Lorlatinib and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zanubrutinib is metabolised mainly by CYP3A4, and lorlatinib is a moderate CYP3A4 inducer. Zanubrutinib exposure may fall, which could compromise disease control.
What this interaction means in plain words
Lorlatinib and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Zanubrutinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4 and increases zanubrutinib clearance.
What to do
Prefer an alternative to lorlatinib where feasible. If unavoidable, zanubrutinib dose increase per labeling for moderate inducers may be needed, with monitoring of the haematological response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Lorlatinib with Zanubrutinib?
MediHelp rates the interaction as moderate. Lorlatinib and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zanubrutinib is metabolised mainly by CYP3A4, and lorlatinib is a moderate CYP3A4 inducer. Zanubrutinib exposure may fall, which could compromise disease control.
How serious is the interaction between Lorlatinib and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to lorlatinib where feasible. If unavoidable, zanubrutinib dose increase per labeling for moderate inducers may be needed, with monitoring of the haematological response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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