Drug interactions
Lorlatinib + Zolpidem
Severity: Moderate
Lorlatinib and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower zolpidem concentrations, possibly reducing its sleep-promoting effect. Lorlatinib itself can cause CNS effects such as mood changes and cognitive effects.
What this interaction means in plain words
Lorlatinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Lorlatinib induces CYP3A4, accelerating the metabolism of zolpidem.
What to do
Monitor for loss of hypnotic efficacy and consider an alternative agent if control is inadequate. Do not exceed the maximum labeled zolpidem dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Zolpidem?
MediHelp rates the interaction as moderate. Lorlatinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower zolpidem concentrations, possibly reducing its sleep-promoting effect. Lorlatinib itself can cause CNS effects such as mood changes and cognitive effects.
How serious is the interaction between Lorlatinib and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of hypnotic efficacy and consider an alternative agent if control is inadequate. Do not exceed the maximum labeled zolpidem dose.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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