Drug interactions
Lormetazepam + Nortriptyline
Severity: Moderate
Lormetazepam and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases sedation and psychomotor impairment, with a higher risk of next-day drowsiness and falls. The effect is most important in older or frail patients.
What this interaction means in plain words
Lormetazepam and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and the sedating properties of nortriptyline.
What to do
Keep doses as low as possible and limit duration of benzodiazepine use. Counsel on avoiding alcohol and driving, and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Lormetazepam with Nortriptyline?
MediHelp rates the interaction as moderate. Lormetazepam and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use increases sedation and psychomotor impairment, with a higher risk of next-day drowsiness and falls. The effect is most important in older or frail patients.
How serious is the interaction between Lormetazepam and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep doses as low as possible and limit duration of benzodiazepine use. Counsel on avoiding alcohol and driving, and monitor for oversedation.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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