Drug interactions
Lormetazepam + Oxazepam
Severity: Moderate
Lormetazepam and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together duplicate therapy and increase sedation, impaired coordination and respiratory depression. Residual next-day impairment may be more pronounced.
What this interaction means in plain words
Lormetazepam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation by two benzodiazepines.
What to do
Avoid using both and consolidate to one agent. If overlap is unavoidable, use minimal doses and monitor for sedation and respiratory compromise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Lormetazepam with Oxazepam?
MediHelp rates the interaction as moderate. Lormetazepam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines taken together duplicate therapy and increase sedation, impaired coordination and respiratory depression. Residual next-day impairment may be more pronounced.
How serious is the interaction between Lormetazepam and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both and consolidate to one agent. If overlap is unavoidable, use minimal doses and monitor for sedation and respiratory compromise.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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