Drug interactions
Loxapine inhaled + Morphine
Severity: Moderate
Loxapine inhaled and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine causes sedation and can cause bronchospasm, and combining it with opioids increases CNS depression. Labeling advises caution with other CNS depressants.
What this interaction means in plain words
Loxapine inhaled and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic sedative effects.
What to do
Monitor sedation and respiratory status after loxapine dosing and consider lowering the morphine dose. Observe patients, especially if respiratory disease is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Loxapine inhaled with Morphine?
MediHelp rates the interaction as moderate. Loxapine inhaled and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine causes sedation and can cause bronchospasm, and combining it with opioids increases CNS depression. Labeling advises caution with other CNS depressants.
How serious is the interaction between Loxapine inhaled and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after loxapine dosing and consider lowering the morphine dose. Observe patients, especially if respiratory disease is present.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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