Drug interactions
Loxapine inhaled + Oxazepam
Severity: Moderate
Loxapine inhaled and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause sedation and bronchospasm, and benzodiazepines add to CNS and respiratory depression. Labeling advises caution with concomitant CNS depressants.
What this interaction means in plain words
Loxapine inhaled and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through dopamine/serotonin antagonism with GABA-A potentiation.
What to do
Administer inhaled loxapine only in a monitored setting and observe for sedation and respiratory symptoms. Be especially cautious with airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Loxapine inhaled with Oxazepam?
MediHelp rates the interaction as moderate. Loxapine inhaled and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine can cause sedation and bronchospasm, and benzodiazepines add to CNS and respiratory depression. Labeling advises caution with concomitant CNS depressants.
How serious is the interaction between Loxapine inhaled and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer inhaled loxapine only in a monitored setting and observe for sedation and respiratory symptoms. Be especially cautious with airway disease.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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