Drug interactions
Loxapine inhaled + Salmeterol
Severity: Moderate
Loxapine inhaled and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause bronchospasm, particularly in patients with airway disease, and this may counter the bronchodilator effect of salmeterol. Patients using long-acting beta-agonists for asthma or COPD are the ones most at risk.
What this interaction means in plain words
Loxapine inhaled and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Loxapine inhalation provokes bronchospasm, pharmacodynamically opposing beta-agonist bronchodilation.
What to do
Inhaled loxapine is restricted to patients without active airway disease and requires a REMS program. Use a short-acting bronchodilator pretreatment as labeled and avoid in patients needing regular salmeterol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Loxapine inhaled with Salmeterol?
MediHelp rates the interaction as moderate. Loxapine inhaled and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine can cause bronchospasm, particularly in patients with airway disease, and this may counter the bronchodilator effect of salmeterol. Patients using long-acting beta-agonists for asthma or COPD are the ones most at risk.
How serious is the interaction between Loxapine inhaled and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inhaled loxapine is restricted to patients without active airway disease and requires a REMS program. Use a short-acting bronchodilator pretreatment as labeled and avoid in patients needing regular salmeterol.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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