Drug interactions
Loxapine inhaled + Selegiline
Severity: Moderate
Loxapine inhaled and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics can enhance serotonergic toxicity, and the combination of dopamine blockade with a dopaminergic MAO-B inhibitor may be counterproductive. Loxapine also has the potential to worsen parkinsonian symptoms. Rare serotonin syndrome or neuroleptic malignant syndrome has been described with similar combinations.
What this interaction means in plain words
Loxapine inhaled and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing dopaminergic effects (D2 blockade versus MAO-B inhibition), with possible additive serotonergic effects.
What to do
Monitor motor function, mental status and temperature. Seek an alternative with less D2 blockade in Parkinson disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Selegiline?
MediHelp rates the interaction as moderate. Loxapine inhaled and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics can enhance serotonergic toxicity, and the combination of dopamine blockade with a dopaminergic MAO-B inhibitor may be counterproductive. Loxapine also has the potential to worsen parkinsonian symptoms. Rare serotonin syndrome or neuroleptic malignant syndrome has been described with similar combinations.
How serious is the interaction between Loxapine inhaled and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function, mental status and temperature. Seek an alternative with less D2 blockade in Parkinson disease.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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