Drug interactions
Lsd + Morphine
Severity: Minor
Lsd and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a serotonergic agonist, and combining it with opioids may add to unpredictable CNS effects. A true serotonin syndrome with morphine is unlikely, and data are very limited.
What this interaction means in plain words
Lsd and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Serotonin 5-HT2A agonism by LSD with weak serotonergic activity from morphine; poorly characterized.
What to do
Counsel against use of illicit LSD and monitor for agitation, hyperthermia and respiratory depression if exposure occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Lsd with Morphine?
MediHelp rates the interaction as minor. Lsd and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. LSD is a serotonergic agonist, and combining it with opioids may add to unpredictable CNS effects. A true serotonin syndrome with morphine is unlikely, and data are very limited.
How serious is the interaction between Lsd and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against use of illicit LSD and monitor for agitation, hyperthermia and respiratory depression if exposure occurs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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