Drug interactions
Lumacaftor / ivacaftor + Metformin-repaglinide
Severity: Moderate
Lumacaftor / ivacaftor and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may induce CYP2C8, lowering repaglinide concentrations. Blood glucose control may worsen.
What this interaction means in plain words
Lumacaftor / ivacaftor and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and CYP2C8 increases repaglinide clearance.
What to do
Monitor blood glucose after starting or stopping lumacaftor/ivacaftor and adjust the repaglinide dose or choose another agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may induce CYP2C8, lowering repaglinide concentrations. Blood glucose control may worsen.
How serious is the interaction between Lumacaftor / ivacaftor and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping lumacaftor/ivacaftor and adjust the repaglinide dose or choose another agent.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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