Drug interactions
Lumacaftor / ivacaftor + Nateglinide
Severity: Moderate
Lumacaftor / ivacaftor and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an inducer and ivacaftor a weak inhibitor of CYP2C9, so the net effect on nateglinide exposure is unpredictable. Glycemic control could be lost if nateglinide levels fall, or hypoglycemia could occur if they rise.
What this interaction means in plain words
Lumacaftor / ivacaftor and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing effects on CYP2C9: induction by lumacaftor and inhibition by ivacaftor alter nateglinide metabolism.
What to do
Monitor blood glucose closely when starting or stopping lumacaftor/ivacaftor and adjust the nateglinide dose according to glycemic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Nateglinide?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is an inducer and ivacaftor a weak inhibitor of CYP2C9, so the net effect on nateglinide exposure is unpredictable. Glycemic control could be lost if nateglinide levels fall, or hypoglycemia could occur if they rise.
How serious is the interaction between Lumacaftor / ivacaftor and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping lumacaftor/ivacaftor and adjust the nateglinide dose according to glycemic response.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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