Drug interactions
Lumacaftor / ivacaftor + Pantoprazole
Severity: Minor
Lumacaftor / ivacaftor and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4, which may lower pantoprazole exposure and weaken acid suppression. The net effect is uncertain because ivacaftor can inhibit some of these pathways.
What this interaction means in plain words
Lumacaftor / ivacaftor and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Net enzyme induction by lumacaftor with some inhibition by ivacaftor alters pantoprazole clearance.
What to do
Monitor for reduced acid control and adjust the pantoprazole dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Pantoprazole?
MediHelp rates the interaction as minor. Lumacaftor / ivacaftor and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4, which may lower pantoprazole exposure and weaken acid suppression. The net effect is uncertain because ivacaftor can inhibit some of these pathways.
How serious is the interaction between Lumacaftor / ivacaftor and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced acid control and adjust the pantoprazole dose as needed.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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