Drug interactions
Lumacaftor / ivacaftor + Selegiline
Severity: Minor
Lumacaftor / ivacaftor and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an inducer of CYP enzymes and could lower selegiline exposure, which is partly metabolized by CYP2B6. Ivacaftor may weakly inhibit CYP2B6, so the net effect is uncertain and probably small.
What this interaction means in plain words
Lumacaftor / ivacaftor and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing in vitro effects on CYP2B6, with induction by lumacaftor likely predominating.
What to do
Monitor for reduced response to selegiline and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Selegiline?
MediHelp rates the interaction as minor. Lumacaftor / ivacaftor and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor is an inducer of CYP enzymes and could lower selegiline exposure, which is partly metabolized by CYP2B6. Ivacaftor may weakly inhibit CYP2B6, so the net effect is uncertain and probably small.
How serious is the interaction between Lumacaftor / ivacaftor and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to selegiline and adjust the dose if needed.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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