Drug interactions
Lumateperone + Metronidazole
Severity: Moderate
Lumateperone and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may increase lumateperone exposure through CYP3A4 inhibition, raising the risk of sedation, orthostatic hypotension and other dose-related adverse effects.
What this interaction means in plain words
Lumateperone and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lumateperone belongs to Central Nervous System; Metronidazole belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by metronidazole reduces lumateperone clearance.
What to do
Reduce lumateperone to 21 mg daily per labeling during moderate CYP3A4 inhibitor use. Monitor for sedation and blood pressure changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lumateperone and Metronidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Lumateperone with Metronidazole?
MediHelp rates the interaction as moderate. Lumateperone and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole may increase lumateperone exposure through CYP3A4 inhibition, raising the risk of sedation, orthostatic hypotension and other dose-related adverse effects.
How serious is the interaction between Lumateperone and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 21 mg daily per labeling during moderate CYP3A4 inhibitor use. Monitor for sedation and blood pressure changes.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
