Drug interactions
Lumefantrine + Repaglinide
Severity: Minor
Lumefantrine and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine may weakly induce CYP3A4, which could lower repaglinide exposure and reduce glycemic control. The clinical impact is likely small and short-lived given the brief antimalarial course.
What this interaction means in plain words
Lumefantrine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by lumefantrine may increase repaglinide metabolism; the mechanism is not firmly established.
What to do
Monitor blood glucose during the antimalarial course and adjust repaglinide only if hyperglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Lumefantrine with Repaglinide?
MediHelp rates the interaction as minor. Lumefantrine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine may weakly induce CYP3A4, which could lower repaglinide exposure and reduce glycemic control. The clinical impact is likely small and short-lived given the brief antimalarial course.
How serious is the interaction between Lumefantrine and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antimalarial course and adjust repaglinide only if hyperglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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