Drug interactions
Lumefantrine + Timolol
Severity: Moderate
Lumefantrine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine can inhibit CYP2D6, which may increase timolol exposure and strengthen beta-blockade. Bradycardia and hypotension are the main concerns, and the effect is short-lived due to brief antimalarial courses.
What this interaction means in plain words
Lumefantrine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumefantrine inhibits CYP2D6, reducing timolol metabolism.
What to do
Monitor heart rate and blood pressure during the antimalarial course. Reduce the timolol dose if symptomatic bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Lumefantrine with Timolol?
MediHelp rates the interaction as moderate. Lumefantrine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine can inhibit CYP2D6, which may increase timolol exposure and strengthen beta-blockade. Bradycardia and hypotension are the main concerns, and the effect is short-lived due to brief antimalarial courses.
How serious is the interaction between Lumefantrine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during the antimalarial course. Reduce the timolol dose if symptomatic bradycardia develops.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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