Drug interactions
Lumefantrine + Triptorelin
Severity: Moderate
Lumefantrine and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, and triptorelin may add to this through androgen deprivation. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Lumefantrine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Consider an ECG before treatment and correct potassium and magnesium. Because the antimalarial course is short, monitor closely or choose a different antimalarial if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lumefantrine and Triptorelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Triptorelin
Frequently asked questions
Can I take Lumefantrine with Triptorelin?
MediHelp rates the interaction as moderate. Lumefantrine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, and triptorelin may add to this through androgen deprivation. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Lumefantrine and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG before treatment and correct potassium and magnesium. Because the antimalarial course is short, monitor closely or choose a different antimalarial if QT risk is high.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
