Drug interactions
Lumefantrine + Vincristine
Severity: Minor
Lumefantrine and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine has been reported to have weak CYP3A4 induction potential, which could theoretically lower vincristine exposure. No clinically meaningful loss of vincristine effect has been documented.
What this interaction means in plain words
Lumefantrine and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak CYP3A4 induction by lumefantrine increasing vincristine clearance.
What to do
No adjustment is needed. Monitor clinical response to vincristine if prolonged antimalarial treatment is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lumefantrine and Vincristine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Lumefantrine with Vincristine?
MediHelp rates the interaction as minor. Lumefantrine and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine has been reported to have weak CYP3A4 induction potential, which could theoretically lower vincristine exposure. No clinically meaningful loss of vincristine effect has been documented.
How serious is the interaction between Lumefantrine and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor clinical response to vincristine if prolonged antimalarial treatment is given.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
