Drug interactions
Lumefantrine + Vinorelbine
Severity: Minor
Lumefantrine and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a CYP3A4 substrate with no established strong induction of the enzyme, so a clinically important fall in vinorelbine exposure is not expected. The interaction is theoretical.
What this interaction means in plain words
Lumefantrine and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not established; a possible weak effect on CYP3A4 has been proposed.
What to do
No adjustment is needed. Monitor treatment response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Lumefantrine with Vinorelbine?
MediHelp rates the interaction as minor. Lumefantrine and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is a CYP3A4 substrate with no established strong induction of the enzyme, so a clinically important fall in vinorelbine exposure is not expected. The interaction is theoretical.
How serious is the interaction between Lumefantrine and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor treatment response as usual.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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