Drug interactions
Lycopus + Repaglinide
Severity: Minor
Lycopus and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lycopus (gypsywort) has been reported to have glucose-lowering and thyroid-modulating properties in preclinical work. Taken with repaglinide it could add to the glucose-lowering effect, although human evidence is lacking.
What this interaction means in plain words
Lycopus and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect; the mechanism is not well established and the interaction is largely theoretical.
What to do
Ask patients about herbal use and monitor blood glucose if lycopus is started or stopped. Reduce the repaglinide dose only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Lycopus with Repaglinide?
MediHelp rates the interaction as minor. Lycopus and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lycopus (gypsywort) has been reported to have glucose-lowering and thyroid-modulating properties in preclinical work. Taken with repaglinide it could add to the glucose-lowering effect, although human evidence is lacking.
How serious is the interaction between Lycopus and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and monitor blood glucose if lycopus is started or stopped. Reduce the repaglinide dose only if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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