Drug interactions
Macitentan + Sildenafil
Severity: Minor
Macitentan and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macitentan produces only a small rise in sildenafil exposure at steady state, which is not expected to change clinical effect. The two drugs are commonly used together in pulmonary arterial hypertension.
What this interaction means in plain words
Macitentan and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Macitentan belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Minor pharmacokinetic change in sildenafil exposure; the mechanism is not clearly established.
What to do
No dose adjustment is needed; monitor blood pressure as routine when the combination is used for pulmonary arterial hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Macitentan and Sildenafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Macitentan
- Amiodarone + Macitentan Major
- Apalutamide + Macitentan Major
- Bosentan + Macitentan Major
- Carbamazepine + Macitentan Major
- Clarithromycin + Macitentan Major
- Efavirenz + Macitentan Major
Frequently asked questions
Can I take Macitentan with Sildenafil?
MediHelp rates the interaction as minor. Macitentan and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macitentan produces only a small rise in sildenafil exposure at steady state, which is not expected to change clinical effect. The two drugs are commonly used together in pulmonary arterial hypertension.
How serious is the interaction between Macitentan and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood pressure as routine when the combination is used for pulmonary arterial hypertension.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
