Drug interactions
Magnesium chloride + Penicillamine
Severity: Moderate
Magnesium chloride and Penicillamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium salts can bind penicillamine in the gastrointestinal tract and lower its absorption. This may reduce penicillamine efficacy.
What this interaction means in plain words
Magnesium chloride and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of penicillamine by magnesium cations in the gut reduces its absorption.
What to do
Give penicillamine at least 2 hours apart from magnesium and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Frequently asked questions
Can I take Magnesium chloride with Penicillamine?
MediHelp rates the interaction as moderate. Magnesium chloride and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium salts can bind penicillamine in the gastrointestinal tract and lower its absorption. This may reduce penicillamine efficacy.
How serious is the interaction between Magnesium chloride and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give penicillamine at least 2 hours apart from magnesium and monitor clinical response.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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