Drug interactions
Carbonyl iron + Penicillamine
Severity: Moderate
Carbonyl iron and Penicillamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron binds penicillamine in the gut and can substantially reduce its absorption, which may lead to reduced therapeutic effect. Stopping iron can later increase penicillamine exposure.
What this interaction means in plain words
Carbonyl iron and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Penicillamine belongs to Musculoskeletal.
Why it happens
Chelation of penicillamine by iron in the gastrointestinal tract reduces absorption.
What to do
Separate doses by at least 2 hours, giving penicillamine on an empty stomach. Monitor clinical response and adjust the dose if iron is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Copper + Penicillamine Moderate
- Digoxin + Penicillamine Moderate
Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Frequently asked questions
Can I take Carbonyl iron with Penicillamine?
MediHelp rates the interaction as moderate. Carbonyl iron and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron binds penicillamine in the gut and can substantially reduce its absorption, which may lead to reduced therapeutic effect. Stopping iron can later increase penicillamine exposure.
How serious is the interaction between Carbonyl iron and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours, giving penicillamine on an empty stomach. Monitor clinical response and adjust the dose if iron is started or stopped.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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