Drug interactions
Magnesium chloride + Streptomycin
Severity: Minor
Magnesium chloride and Streptomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal tubular magnesium wasting, leading to hypomagnesemia during prolonged therapy. Low magnesium may cause muscle weakness, arrhythmias and secondary hypokalemia or hypocalcemia. Magnesium given as a supplement may offset this loss.
What this interaction means in plain words
Magnesium chloride and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aminoglycoside-induced renal tubular injury increases urinary magnesium excretion.
What to do
Monitor serum magnesium, potassium and calcium during prolonged streptomycin courses and replace magnesium as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Magnesium chloride with Streptomycin?
MediHelp rates the interaction as minor. Magnesium chloride and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminoglycosides can cause renal tubular magnesium wasting, leading to hypomagnesemia during prolonged therapy. Low magnesium may cause muscle weakness, arrhythmias and secondary hypokalemia or hypocalcemia. Magnesium given as a supplement may offset this loss.
How serious is the interaction between Magnesium chloride and Streptomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and calcium during prolonged streptomycin courses and replace magnesium as needed.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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