Drug interactions
Magnesium chloride + Tobramycin
Severity: Minor
Magnesium chloride and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia during prolonged therapy. Magnesium supplementation may be needed, and low magnesium also worsens associated potassium and calcium disturbances.
What this interaction means in plain words
Magnesium chloride and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aminoglycoside-induced renal tubular injury increases urinary magnesium excretion.
What to do
Monitor serum magnesium, potassium and calcium during prolonged tobramycin therapy and replace magnesium as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Magnesium chloride with Tobramycin?
MediHelp rates the interaction as minor. Magnesium chloride and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia during prolonged therapy. Magnesium supplementation may be needed, and low magnesium also worsens associated potassium and calcium disturbances.
How serious is the interaction between Magnesium chloride and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and calcium during prolonged tobramycin therapy and replace magnesium as needed.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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