Drug interactions
Magnesium sulfate + Nifedipine
Severity: Moderate
Magnesium sulfate and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous magnesium sulfate combined with nifedipine, as in obstetric use, can cause additive hypotension and rarely neuromuscular weakness. Reports describe profound blockade and hypotension in some patients.
What this interaction means in plain words
Magnesium sulfate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and calcium antagonism at neuromuscular junctions and vascular smooth muscle.
What to do
Monitor blood pressure, deep tendon reflexes and respiratory function during coadministration. Stop or reduce magnesium if weakness or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Magnesium sulfate with Nifedipine?
MediHelp rates the interaction as moderate. Magnesium sulfate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous magnesium sulfate combined with nifedipine, as in obstetric use, can cause additive hypotension and rarely neuromuscular weakness. Reports describe profound blockade and hypotension in some patients.
How serious is the interaction between Magnesium sulfate and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, deep tendon reflexes and respiratory function during coadministration. Stop or reduce magnesium if weakness or hypotension develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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