Drug interactions
Magnesium sulfate + Penicillamine
Severity: Moderate
Magnesium sulfate and Penicillamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium sulfate may bind penicillamine in the gut and reduce its absorption. Intravenous magnesium sulfate would not be expected to act this way.
What this interaction means in plain words
Magnesium sulfate and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of penicillamine by magnesium cations in the gastrointestinal lumen reduces absorption.
What to do
If oral magnesium sulfate is used, separate it from penicillamine by at least 2 hours and monitor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Frequently asked questions
Can I take Magnesium sulfate with Penicillamine?
MediHelp rates the interaction as moderate. Magnesium sulfate and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium sulfate may bind penicillamine in the gut and reduce its absorption. Intravenous magnesium sulfate would not be expected to act this way.
How serious is the interaction between Magnesium sulfate and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If oral magnesium sulfate is used, separate it from penicillamine by at least 2 hours and monitor response.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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