Drug interactions
Magnesium sulfate + Spironolactone
Severity: Minor
Magnesium sulfate and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone reduces urinary magnesium loss, which may add to magnesium accumulation during magnesium sulfate therapy. Risk is greatest with parenteral dosing or reduced renal function.
What this interaction means in plain words
Magnesium sulfate and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aldosterone antagonism reduces renal magnesium excretion, adding to administered magnesium load.
What to do
Monitor serum magnesium and renal function during parenteral magnesium sulfate in patients taking spironolactone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Magnesium sulfate with Spironolactone?
MediHelp rates the interaction as minor. Magnesium sulfate and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone reduces urinary magnesium loss, which may add to magnesium accumulation during magnesium sulfate therapy. Risk is greatest with parenteral dosing or reduced renal function.
How serious is the interaction between Magnesium sulfate and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function during parenteral magnesium sulfate in patients taking spironolactone.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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