Drug interactions
Magnesium sulfate + Streptomycin
Severity: Moderate
Magnesium sulfate and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral magnesium sulfate has neuromuscular blocking activity, and aminoglycosides also impair neuromuscular transmission, so together they may cause enhanced muscle weakness or respiratory depression. Aminoglycosides can also waste magnesium through the kidney.
What this interaction means in plain words
Magnesium sulfate and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic effects, plus aminoglycoside-induced renal magnesium loss.
What to do
Monitor respiratory function and neuromuscular status when giving parenteral magnesium sulfate with streptomycin, and check serum magnesium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Magnesium sulfate and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Streptomycin
Frequently asked questions
Can I take Magnesium sulfate with Streptomycin?
MediHelp rates the interaction as moderate. Magnesium sulfate and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate has neuromuscular blocking activity, and aminoglycosides also impair neuromuscular transmission, so together they may cause enhanced muscle weakness or respiratory depression. Aminoglycosides can also waste magnesium through the kidney.
How serious is the interaction between Magnesium sulfate and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory function and neuromuscular status when giving parenteral magnesium sulfate with streptomycin, and check serum magnesium and renal function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
