Drug interactions
Magnesium sulfate + Triamterene
Severity: Minor
Magnesium sulfate and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is potassium-sparing and has magnesium-sparing effects, reducing renal magnesium excretion. With magnesium sulfate, particularly parenteral, serum magnesium may rise more than expected, especially in renal impairment.
What this interaction means in plain words
Magnesium sulfate and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Triamterene reduces renal magnesium excretion, adding to magnesium exposure.
What to do
Monitor serum magnesium and renal function, and check reflexes during parenteral magnesium therapy. Reduce the magnesium dose if levels rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Magnesium sulfate with Triamterene?
MediHelp rates the interaction as minor. Magnesium sulfate and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triamterene is potassium-sparing and has magnesium-sparing effects, reducing renal magnesium excretion. With magnesium sulfate, particularly parenteral, serum magnesium may rise more than expected, especially in renal impairment.
How serious is the interaction between Magnesium sulfate and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function, and check reflexes during parenteral magnesium therapy. Reduce the magnesium dose if levels rise.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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