Drug interactions
Magnesium supplement + Raltegravir
Severity: Major
Magnesium supplement and Raltegravir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium supplements can reduce raltegravir absorption, potentially lowering antiviral exposure. Effect depends on the formulation and timing, and the 1200 mg film-coated once-daily regimen is particularly affected.
What this interaction means in plain words
Magnesium supplement and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Magnesium chelates raltegravir in the gut, forming poorly absorbed complexes.
What to do
Avoid concurrent use where possible; if a magnesium supplement is essential, separate dosing widely and monitor viral load.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Frequently asked questions
Can I take Magnesium supplement with Raltegravir?
MediHelp rates the interaction as major. Magnesium supplement and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral magnesium supplements can reduce raltegravir absorption, potentially lowering antiviral exposure. Effect depends on the formulation and timing, and the 1200 mg film-coated once-daily regimen is particularly affected.
How serious is the interaction between Magnesium supplement and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if a magnesium supplement is essential, separate dosing widely and monitor viral load.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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