Drug interactions
Magnesium supplement + Streptomycin
Severity: Moderate
Magnesium supplement and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both magnesium and aminoglycosides weaken neuromuscular transmission. Together, particularly with parenteral magnesium or high doses, they may cause additive muscle weakness and respiratory depression.
What this interaction means in plain words
Magnesium supplement and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic effects.
What to do
Monitor respiratory function and muscle strength if streptomycin is given with parenteral or high-dose magnesium. Keep serum magnesium in the normal range and be especially careful in patients with renal impairment or myasthenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Magnesium supplement with Streptomycin?
MediHelp rates the interaction as moderate. Magnesium supplement and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both magnesium and aminoglycosides weaken neuromuscular transmission. Together, particularly with parenteral magnesium or high doses, they may cause additive muscle weakness and respiratory depression.
How serious is the interaction between Magnesium supplement and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory function and muscle strength if streptomycin is given with parenteral or high-dose magnesium. Keep serum magnesium in the normal range and be especially careful in patients with renal impairment or myasthenia.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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