Drug interactions
Magnesium supplement + Tiludronate
Severity: Moderate
Magnesium supplement and Tiludronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium forms insoluble chelates with tiludronate in the gut, which lowers its absorption. The bisphosphonate effect may be reduced if they are taken together.
What this interaction means in plain words
Magnesium supplement and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of tiludronate by magnesium in the gastrointestinal tract reduces absorption.
What to do
Separate tiludronate from magnesium supplements by at least 2 hours, taking tiludronate on an empty stomach.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiludronate
- Acetylsalicylic acid + Tiludronate Moderate
- Aluminum hydroxide + Tiludronate Moderate
- Calcium acetate + Tiludronate Moderate
- Calcium carbonate + Tiludronate Moderate
- Calcium chloride + Tiludronate Moderate
- Calcium citrate + Tiludronate Moderate
Frequently asked questions
Can I take Magnesium supplement with Tiludronate?
MediHelp rates the interaction as moderate. Magnesium supplement and Tiludronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium forms insoluble chelates with tiludronate in the gut, which lowers its absorption. The bisphosphonate effect may be reduced if they are taken together.
How serious is the interaction between Magnesium supplement and Tiludronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate tiludronate from magnesium supplements by at least 2 hours, taking tiludronate on an empty stomach.
What other medicines interact with Tiludronate?
MediHelp also lists interactions of Tiludronate with, for example, Acetylsalicylic acid, Aluminum hydroxide, Calcium acetate. The full list is on the Tiludronate page.
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