Drug interactions
Maitake + Sacubitril-valsartan
Severity: Minor
Maitake and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake mushroom has been reported to have blood pressure lowering activity, which could add to the effect of sacubitril-valsartan. The evidence is limited and clinically significant hypotension is not well documented.
What this interaction means in plain words
Maitake and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive antihypertensive effect; the mechanism is not well established.
What to do
Monitor blood pressure if maitake supplements are started or stopped during sacubitril-valsartan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Maitake with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Maitake and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maitake mushroom has been reported to have blood pressure lowering activity, which could add to the effect of sacubitril-valsartan. The evidence is limited and clinically significant hypotension is not well documented.
How serious is the interaction between Maitake and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if maitake supplements are started or stopped during sacubitril-valsartan therapy.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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