Drug interactions
Albuterol + Maprotiline
Severity: Moderate
Albuterol and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic-type antidepressants can potentiate the cardiovascular effects of beta-agonists, leading to tachycardia, arrhythmia or blood pressure changes. The effect is mainly of concern with systemic albuterol and is much less significant with inhaled doses.
What this interaction means in plain words
Albuterol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Maprotiline blocks norepinephrine reuptake and may have additive adrenergic cardiovascular effects with beta-agonists; maprotiline also has QT-prolonging potential.
What to do
Monitor heart rate, blood pressure and ECG if albuterol is given orally or in high nebulized doses. Standard inhaled doses usually need no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Albuterol with Maprotiline?
MediHelp rates the interaction as moderate. Albuterol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic-type antidepressants can potentiate the cardiovascular effects of beta-agonists, leading to tachycardia, arrhythmia or blood pressure changes. The effect is mainly of concern with systemic albuterol and is much less significant with inhaled doses.
How serious is the interaction between Albuterol and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG if albuterol is given orally or in high nebulized doses. Standard inhaled doses usually need no change.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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