Drug reference
maprotiline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Tricyclic Antidepressants)
Mechanism of action
Tetracyclic; may increase norepinephrine synaptic concentrations in the central nervous system by blocking NE reuptake by the presynaptic neuronal membrane; may also down regulate serotonin receptors and beta-adrenergic receptors and desensitize adenyl cyclase
Common side effects
- Constipation
- Sedation
- Blurred vision
- Fatigue
- Lethargy
- Weakness
Known interactions (2)
- isocarboxazid + maprotiline Contraindicated
- indapamide + maprotiline Moderate
Related conditions
Frequently asked questions
What drug class is maprotiline?
maprotiline belongs to: Central Nervous System.
How does maprotiline work?
Tetracyclic; may increase norepinephrine synaptic concentrations in the central nervous system by blocking NE reuptake by the presynaptic neuronal membrane; may also down regulate serotonin receptors and beta-adrenergic receptors and desensitize adenyl cyclase
What are the common side effects of maprotiline?
Constipation, Sedation, Blurred vision, Fatigue, Lethargy, Weakness
Which drugs interact with maprotiline?
isocarboxazid, indapamide
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