Drug interactions
Marijuana + Nifedipine
Severity: Minor
Marijuana and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause tachycardia and orthostatic hypotension, which may add to the vasodilatory effects of nifedipine. Cannabidiol also inhibits CYP3A4 in vitro and could raise nifedipine exposure.
What this interaction means in plain words
Marijuana and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive cardiovascular effects with possible CYP3A4 inhibition by cannabinoids.
What to do
Counsel the patient about dizziness and fainting, and monitor blood pressure and heart rate in regular cannabis users on nifedipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Marijuana with Nifedipine?
MediHelp rates the interaction as minor. Marijuana and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabis can cause tachycardia and orthostatic hypotension, which may add to the vasodilatory effects of nifedipine. Cannabidiol also inhibits CYP3A4 in vitro and could raise nifedipine exposure.
How serious is the interaction between Marijuana and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about dizziness and fainting, and monitor blood pressure and heart rate in regular cannabis users on nifedipine.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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