Drug interactions
Marijuana + Nilotinib
Severity: Moderate
Marijuana and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis constituents, especially cannabidiol, may inhibit CYP3A4 and could raise nilotinib concentrations. Increased nilotinib exposure raises the risk of QT prolongation and other dose-related toxicity.
What this interaction means in plain words
Marijuana and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 inhibition by cannabinoids reducing nilotinib metabolism.
What to do
Counsel patients about this potential effect and monitor ECG and adverse effects if use continues. Discourage cannabis use during nilotinib therapy where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Marijuana with Nilotinib?
MediHelp rates the interaction as moderate. Marijuana and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis constituents, especially cannabidiol, may inhibit CYP3A4 and could raise nilotinib concentrations. Increased nilotinib exposure raises the risk of QT prolongation and other dose-related toxicity.
How serious is the interaction between Marijuana and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about this potential effect and monitor ECG and adverse effects if use continues. Discourage cannabis use during nilotinib therapy where practical.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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